ST. LOUIS — All scoring stopped from the fifth inning on, as the Cardinal offense withered.
Tyler Lyons went 4.2 innings in relief, striking out eight and facing the minimum, a lone bright spot in an otherwise brutal showing.
Game 2 will be at 7:15 following the 5-1 loss.
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Lyons retired eight straight hitters, effectively stopping the Cubs offense. Unfortunately, the Cardinals went nine up and nine down over that stretch, failing to mount any credible threat.
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Masterson was pushed from the game when the Cubs hit their third home run in the fifth inning.
It came from Starlin Castro, his 14th of the year, and pushed the lead to 5-1. Tyler Lyons came in to relieve Masterson, who left the game with 82 pitches in 4.1 innings. He fanned five but allowed three homers, pushing his ERA to 6.03.
Lyons got the final two outs without incident.
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The Cubs continued to show power, adding to their lead with back-to-back bombs to start off the fourth inning.
First, Logan Watkins opened things with his first career home run. It sailed over Grichuk’s head and into the bullpen for a 3-1 lead.
Right behind him, Chris Valaika pumped his second homer of the year out into the left field bullpen to make it 4-1.
Masterson finished out the inning without another base runner, but Busch Stadium is playing host to an impressive power show.
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The Cardinals answered quickly in the second, when Jhonny Peralta led off with a double and promptly moved to third on a single from Pierzynski.
St. Louis picked up a run, but it cost two outs when Jon Jay grounded into a 4-6-3 double play.
Daniel Descalso singled to start things again, but Masterson grounded out to end the scoring.
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Justin Masterson pitched his way into trouble in the second, loading the bases with two outs.
After a leadoff strike out, Logan Watkins singled. Masterson hit the next batter to put two on, but got Jon Baker to fly out to center field for the second out.
He followed that by walking Felix Doubront to load the bases to face leadoff man Chris Coghlan.
After ripping one just foul down the right field line, the center fielder punched a ball through into right past the diving Descalso.
The hit scored one, but as the Cubs sent Chris Valaika around third, Randal Grichuk scooped up the ball and fired home.
It was a close play, but the call on the field was ruled an out. Rick Renteria came out and asked for a crew chief review of a possible violation of rule 7.13 that says a catcher cannot block the plate.
A.J. Pierzynski was safely out of the way, but by asking for a review of 7.13, the Cubs did not have to spend a challenge to get the replay official to look at the play.
After a review, there was no violation of the rule, but Valaika was ruled safe at the plate.
The inning ended with a ground out one hitter later, but the Cubs headed to the dugout with a 2-0 lead.