The tickets were sold in Florida - the latest state to join Mega Millions - and one of the game's founding members, Maryland.
The winning numbers were 11, 19, 24, 33, 51 -- and the Mega Ball of 7.
In addition to the two jackpot winners, the March 18 draw included eight $1 million "Match 5" winners.
Florida lottery officials say their winning ticket was sold at a Sunoco convenience store in Merritt Island. Information about the Maryland ticket wasn't immediately available.
The jackpot is the sixth-largest lottery prize in U.S. history, with a lump-sum option of $224 million.
Mega Millions changed its rules in October to help increase jackpots by lowering the odds of winning the top prize.
Mega Millions is played in 43 states, the District of Columbia and the U.S. Virgin Islands.