(BaseballStL) -- MLB's save leader Trevor Rosenthal, with 33, came in the ninth to try and add to his lead.
He allowed a lead of dinky hit to Khris Davis, but was able to fan Mark Reynolds and pinch hitter Scooter Gennett.
Carlos Gomez came up to bat with runners on first and second with two outs, the last hope for his team. But Rosenthal threw nothing but high heat fastballs to strike him out looking and earn his 34th save of the season.
The Cardinals move within 1.0 game of first place in the central. John Lackey does earn the victory, which serves as the 150th of his career.
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It took seven innings for the Cardinals to finally score a run and it was scorched ball to center from Matt Holliday that broke the shut-out.
In a puzzling move, the Brewers lifted started Matt Garza for a pinch hitter in the sixth. Garza had only thrown 71 pitches and allowed just one hit, a double in the fifth.
Zach Duke came into relieve Garza and was able to get Kolten Wong to ground out. But in stepped Matt Holliday who has a career .462 average against Duke. On a 3-1 count, Holliday crushed the ball to dead center for 442 feet. That his sixth homer since the All-Star break.
Matt Adams and Jhonny Peralta followed up the homer with back-to-back singles into center field. Then in his first series as a Cardinal, AJ Pierzynski singled into right field as Adams motored all the way home from second to tie the game.
Oscar Taveras got in on the RBI action as he singled home Peralta, allowing Pierzynski to go to third. Taveras was clearly pumped with his go ahead RBI, pumping his fist in the air as he ran to first.
A sacrifice bunt from Peter Bourjos put Taveras on second and brought up Daniel Descalso as a pinch hitter.
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For all three games the Brewers have played against the Cardinals this weekend at Busch Stadium, one thing has remained constant - Aramis Ramirez has scored the first run in each game.
In his first start for the Cardinals, John Lackey made quick work of the Brewers' first two batters, Carlos Gomez and Jonothan Lucroy, getting the first to strike out and the other to foul out.
But Ryan Braun stroked a double into the right field corner and Ramirez singled him home for the first run of the game.
A wild pitch let Ramirez advance to second base with Rickie Weeks at the plate, but Lackey fanned Weeks to end the inning.
In the second inning, on a 1-0 count Mark Reynolds blasted a shot well into the seats in left field to give the Brewers a 2-0 lead.